The calculation is based on the formula developed in
Thomen et al., ACS Nano, 2020 :
[Drug] = (δ13CROIPDB-
δ13CcontrolPDB) x 0.606/N13C
where N13C is the number of 13C per pure drug molecule.
The detection limit of the drug is calculated as :
DL[Drug] = 1000
×
√[ (s × Ip)/(
13C12C-
×
(Diameter/2)2
×
π
×
depth*10×-9))
×
0.606/N13C )
where depth is the depth at which the use clicked on the plot,
13C12C- as total counts, s the sputtering rate equal to
0.83 nm/(s.pA/μm2), Ip is the primary current in pA.
Depth_nm is the depth clicked on the plot by the mouse.
Uncertainty_mM is the uncertainty on the Concentration_mM
defined as a Poisson uncertainty.
Cube_edge_nm is the length of the edge of a
cube equivalent to the cylindrical volume of the
feature ((input diameter/2)2 × π × Depth_nm
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