Molecular content calculator

Diameter of sphere in volume equivalent/nm

        
Last point concentration :

        

        
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 The calculation is based on the formula developed in
              Thomen et al., ACS Nano, 2020 :
              

             [Drug] = (δ13CROIPDB-
             δ13CcontrolPDB) x 0.606/N13C
             where N13C is the number of 13C per pure drug molecule.
             
 The detection limit of the drug is calculated as :

             DL[Drug] = 1000 
             × 
             √[ (s × Ip)/(
             13C12C-
             ×
             (Diameter/2)2 
             ×
             π 
             ×
             depth*10×-9))
             ×
             0.606/N13C )
             

             where depth is the depth at which the use clicked on the plot, 
             13C12C- as total counts, s the sputtering rate equal to
             0.83 nm/(s.pA/μm2), Ip is the primary current in pA.
             

          

            

              

              Depth_nm is the depth clicked on the plot by the mouse.
                      

                      Uncertainty_mM is the uncertainty on the Concentration_mM
                      defined as a Poisson uncertainty.
                      

                      Cube_edge_nm is the length of the edge of a
                      cube equivalent to the cylindrical volume of the 
                      feature ((input diameter/2)2 × π × Depth_nm 
                      

              
                
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